Neuroblastoma is one of the most common solid tumors in children outside the central nervous system. It typically occurs in the abdomen or pelvis and frequently affects very young children. Aggressive treatment regimens, often including chemotherapy, surgery, and radiation, have dramatically increased the cure rate over the past five decades. In patients requiring radiation, research suggests that proton therapy is associated with a reduced radiation dose to the bowel, stomach, kidney, and other abdominal organs. This is important in young patients who are still recovering from the effects of high dose chemotherapy. University of Florida Health Proton Therapy Institute participates in the international Children’s Oncology Group study, ANBL12P1, for neuroblastoma.