For your convenience, we’ve included a list of grocery, drugstores and popular places to shop in this local shopping guide. Although all major shopping areas are listed, we included grocery and drugstores close to the University of Florida Health Proton Therapy Institute only.Information is subject to change. Please call ahead for details.

Neighborhood Shopping Areas

Five Points in Riverside

about 5 miles away

Five Points in Riverside is an urban oasis of shopping, dining, and parks located just south of Downtown. It is nestled in a little corner of an older, character-filled section of Jacksonville called Riverside. The vintage flavor of the area attracts many unique restaurants and shops. A very interesting neighborhood for people watching, Five Points has been a center for counter-culture youth for decades. In recent years, upscale vendors and luxury housing has brought a mix of stores to the area including tattoo parlors, independent music stores, antique boutiques, clothing stores and art galleries. FYI: The Shoppes of Avondale are just a couple of miles down the road (description below). From the Institute, head south on N. Jefferson Street. This road turns into Riverside Ave. You will travel around 2 miles and pass Memorial Park on your left. At that light turn right onto Margaret St. and head straight a couple blocks and you are there.

San Marco Square

about 5 miles away

One of Jacksonville's trendiest destinations, San Marco Square is an artsy shopping, dining and entertainment district on the Southbank of Downtown. You can stroll through art galleries, boutiques, independent bookstores, and upscale gift shops while trying to decide if you want to dine upscale (i.e., Taverna) or more casual (i.e., Seafood Island Bar & Grille). The streets south of the Square are lined with regal old estates and riverfront mansions certainly worth a look. The area gets busy during the lunch hour, when the downtown crowd comes over for a bite to eat, and again when they return for a happy hour or dinner. If all of the on-street parking spaces are taken, there is a large parking lot behind the shops and restaurants lining Atlantic Boulevard. For more information on this area, check out the “Dining” & “Theaters” sections. From the Institute, take 8th Street to I-95 South, go over the river, and get off at the very first exit: “San Marco.” Make a right on San Marco Blvd, the second light, and follow it down a half mile or so.

The Shoppes of Avondale

about 8 miles away

In the heart of Jacksonville's historic Avondale neighborhood lies a strip of boutiques, antique stores, bistros, restaurants and gift shops along St. Johns Avenue. While quieter and smaller in scale than other upscale pedestrian shopping districts around Jacksonville, The Shoppes is one of the oldest. The small commercial strip is nestled in the midst of restored homes built in the early 1900s. The neighborhood is filled with families, joggers, dog walkers, and young professionals. Boone Park, a scenic city park with lots of trees, a few hills, a stream, and a lovely children's playground is just a short walk from The Shoppes. If you work up an appetite shopping, restaurants such as Biscottis, The Brick, Mojo’s and Casbah Café provide fantastic eating options. FYI: Five Points in Riverside is just a couple miles down the road (description above) from the Institute head south on N. Jefferson Street. This road turns into Riverside Ave.You will travel on this road about 5 miles. Make a left on King Street, by St. Vincent’s Hospital. Take King Street one block, then make a right on to St. Johns Avenue. Take this down about 1 mile and you’re there.

Malls & Shopping Centers

River City Marketplace

about 10 miles away

The only major shopping hub on the Northside of the city, this outdoor shopping center is anchored by large national chains like Old Navy; Bed, Bath & Beyond; Lowes; PetSmart and Wal-Mart. It also has many other smaller retail options, casual restaurants and a 14-screen movie theater.

St. Johns Town Center

about 15 miles away

The most upscale and posh shopping center in town, the St. Johns Town Center offers a variety of medium- and high-end stores. Various shops and department stores line this outdoor mall’s version of “Main Street USA.” Aesthetically pleasing and beautifully kept, the grounds also have many places to grab a tasty snack or to enjoy a delicious meal. Valet parking is available as well


about 14 miles away

A large and upscale cinema just 5 minutes from the St. Johns Town Center, recently renovated Tinseltown Cinema is a great place to spend your weekend. Surrounded by restaurants and bars such as Terra Gaucha Brazilian Steakhouse, Mellow Mushroom, Seven Bridges Grille & Brewery, Bento Asian Kitchen & Sushi, and Culhane’s Irish Pub, this is a great spot for a night of fun. All restaurants are within walking distance of the cinema.

Riverside Arts Market

about 3.5 miles away

Riverside Arts Market is a weekly market hosted on Saturdays. RAM features a variety of small businesses from farmers to artists to makers and bakers. Under the Fuller Warren Bridge, you’ll find a family-friedly event that attracts 4,000+ visitors every Saturday. The riverfront ampitheatre seats 350 people and features hours of live music. Starting from the arts market, feel free to take a walk along Jacksonville’s Southbank Riverwalk. The 1 ¼ mile art-filled boardwalk is usually filled with joggers, dog walkers, and tourists, while showing off the beautiful views of downtown Jacksonville.

The Avenues Mall

about 15 miles away

This two-story mall offers your typical suburban shopping options, a food court and movie theater down the street. The Avenues has everything you would expect in a mall, but also caters to those with a higher income by housing some high-end stores as well. Nicely maintained and kept, the mall is near many restaurants on Southside Boulevard.

Orange Park Mall

about 20 miles away

This mall is technically in Orange Park, a suburb of Jacksonville, but you wouldn’t know you left the city. Orange Park Mall contains a food court, attached movie theater and department stores including Dick’s Sporting Goods. The Orange Park Mall caters to median incomes. There are many nice stores but none decidedly high-end.

Sawgrass Village

about 25 miles away

Located in Ponte Vedra Beach, this outdoor shopping area contains a wide variety of unique shops for men, women, children and home, as well as art galleries and upscale restaurants. In addition, local residents often shop in Sawgrass Village’s grocery and drug stores for everyday needs.

St. Augustine Premium Outlets

about 36 miles away

If you’re willing to drive south a little way, you can find some relatively good deals at the St. Augustine Premium Outlets. This outdoor strip mall has a wide variety of stores (about 70) catering to median-high incomes. Coach, Off-Saks, Gucci, Calvin Klein and Polo are some of the higher-end shops. Jewelry, gift, children’s clothing and shoe stores are plentiful as well. It’s almost mandatory to stop and peruse your favorite brands if you’re driving to or from St. Augustine.

Grocery Stores

Publix Supermarkets

about 4-9 miles away

Publix Supermarkets is arguably the most popular grocery store chain in the city and region. Known for friendliness and cleanliness, it has everything you would expect a major grocery chain to have. Many locations have pharmacies as well. Publix caters to median and upper incomes. Below are the three locations closest to Florida Proton:

Store Locator

Winn-Dixie Supermarkets

about 7-12 miles away

A grocery store chain based in Jacksonville, Winn-Dixie Supermarkets have most everything you would expect a major grocery store to have, though some are lacking. Known for their low prices, Winn-Dixie caters to mostly median incomes. We have one conveniently located close by on North Market Street.

Store Locator

Natural & Organic Food Stores

Grassroots Natural Market

This local natural foods store is relatively small, yet varied in its inventory. You’ll find all kinds of organic and natural products including fresh produce, supplements, and made-to-order sandwiches and smoothies. Outdoor seating lets you enjoy beautiful parks nearby and the Five Points shopping area.

Whole Foods Market

about 15 miles away

A national chain proven to provide some of the freshest and organic products around. This store is about 15 minutes south of University of Florida Health Proton Therapy Institute.

Drug Stores & Pharmacies


about 1-4 miles away

Walgreens is a national chain of traditional drugstores and pharmacies. You’ll find a little bit of everything: food, cosmetics, magazines, office supplies, toiletries, photo development, toys, and, of course, medicines of all types. Some have 24-hour pharmacies.

Store Locator

CVS Pharmacies

about 7-8 miles away

CVS Pharmacy is another national drugstore chain that sells various retail, grocery and medicinal items. Some have 24-hour pharmacies.

Store Locator

Wholesale Membership Stores

Sam’s Club

about 7 miles away

This national chain sells in bulk at discounted prices. You can find groceries, electronics, clothing, office supplies, home goods, pharmacy, photo development and many other items at Sam’s. You must have a membership to shop here.


about 15 miles away

This members-only wholesale store is similar to Sam’s Club in that it offers a pharmacy and bulk goods at discounted prices. It’s unique, however, in that it sells higher-end goods as well, but does not have as many grocery items.