Research Portfolio

Exploring the Possibilities of Proton Therapy

At the University of Florida Health Proton Therapy Institute, confidence doesn't just come from the cancer treatments we provide to our patients every day. We draw confidence from the unexplored possibilities of cancer treatment. What's more, we work every day to expand the power of proton therapy – for today's patients, and tomorrow's.

UF Health Proton Therapy Institute published research

Comparsion Image - Proton Therapy is on the left, IMRT is on the right.

Publications 2006 – Present Last updated July 25, 2012

  1. Nichols Jr. RC, Henderson RH, Huh S, Flampouri S, Li Z, Bajwa AA, D'Agostino HJ, Pham DC, Mendenhall NP, Hoppe BS. Proton therapy for lung cancer. Thoracic Cancer 2012 May;3(2):109-116.
  2. Mendenhall WM, Henderson RH, Hoppe BS, Nichols RC, Mendenhall NP. Salvage of Locally Recurrent Prostate Cancer After Definitive Radiotherapy. Am J Clin Oncol. 2012 Jul 3. [Epub ahead of print] PubMed PMID: 22772432.
  3. Hoppe BS, Flampouri S, Lynch J, Slayton W, Zaiden R, Li Z, Mendenhall NP. Improving the therapeutic ratio in Hodgkin lymphoma through the use of proton therapy. Oncology (Williston Park). 2012 May;26(5):456-9, 462-5. PubMed PMID: 22730602.
  4. Dallas J, Imanirad I, Rajani R, Dagan R, Subbiah S, Gaa R, Dwarica WA, Ivey AM, Zlotecki RA, Malyapa R, Indelicato DJ, Scarborough MT, Reith JD, Gibbs CP, Dang LH. Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report. J Med Case Rep. 2012 Jan 30;6:41. PubMed PMID: 22289277; PubMed Central PMCID: PMC3277477.
  5. Swanson EL, Indelicato DJ, Louis D, Flampouri S, Li Z, Morris CG, Paryani N, Slopsema R. Comparison of Three-Dimensional (3D) Conformal Proton Radiotherapy (RT), 3D Conformal Photon RT, and Intensity-Modulated RT for Retroperitoneal and Intra-Abdominal Sarcomas. Int J Radiat Oncol Biol Phys. 2012 Aug 1;83(5):1549-57. Epub 2012 Jan 21. PubMed PMID: 22270176.
  6. Mendenhall WM, Hoppe BS, Nichols RC, Henderson RH, Mendenhall NP. When Is Elective Pelvic Lymph Node Irradiation Indicated in Definitive Radiotherapy for Localized Prostate Cancer? Am J Clin Oncol. 2012 Jan 10. [Epub ahead of print] PubMed PMID: 22237149.
  7. Nichols Jr. RC, Huh S, Henderson RH, Li Z, Flampouri S, D'Agostino HJ, Cury JD, Pham DC, Mendenhall NP, Hoppe BS. Selective nodal irradiation of regionally advanced non-small-cell lung cancer with proton therapy and IMRT: A dosimetric comparison. Thoracic Cancer 2012 May;3(2):169-174.
  8. Shi W, Nichols Jr RC, Flampouri S, Li Z, His W, Huh S, Ho MW, Henderson RH, Mendenhall NP, Hoppe BS. Proton-Based Chemoradiation for Synchronous Bilateral Non-Small-Cell Lung Cancers: A Case Report. Thoracic Cancer 2012;Epub ahead of print. DOI: 10.1111/j.1759-7714.2012.00141.x
  9. Shi W, Nichols RC, Flampouri S, His W, Li Z, Henderson RH, Mendenhall NP, Hoppe B. Tumour Shrinkage during Proton-based Chemoradiation forNon–small-cell Lung Cancer May Necessitate Adaptive Replanning during Treatment. Hong Kong J Radiol. 2011;14:190-4
  10. Hoppe BS, Flampouri S, Henderson RH, Pham D, Bajwa AA, D'Agostino H, Huh SN, Li Z, Mendenhall NP, Nichols RC. Proton Therapy With Concurrent Chemotherapy for Non-small-cell Lung Cancer: Technique and Early Results. Clin Lung Cancer. 2012 Jan 18. [Epub ahead of print] PubMed PMID: 22264659.
  11. Hoppe BS, Nichols RC, Henderson RH, Morris CG, Williams CR, Costa J, Marcus RB Jr, Mendenhall WM, Li Z, Mendenhall NP. Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger. Cancer. 2012 Jan 17. doi: 10.1002/cncr.27398. [Epub ahead of print] PubMed PMID: 22253020.
  12. Nichols RC Jr, Huh SN, Prado KL, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall NP, Li Z, Regine WF. Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer. Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):158-63. Epub 2012 Jan 13. PubMed PMID: 22245197.
  13. Su Z, Lopatiuk-Tirpak O, Zeidan O, Sruprisan SI, Meeks SL, Slopsema R, Flampouri S, Li Z. An experimental investigation into the effect of periodic motion on proton dosimetry using polymer gel dosimeters and a programmable motion platform. Phys Med Biol. 2012 Feb 7;57(3):649-63. Epub 2012 Jan 12. PubMed PMID: 22241573.
  14. Mendenhall WM, Hoppe BS, Nichols RC, Henderson RH, Mendenhall NP. When Is Elective Pelvic Lymph Node Irradiation Indicated in Definitive Radiotherapy for Localized Prostate Cancer? Am J Clin Oncol. 2012 Jan 10. [Epub ahead of print] PubMed PMID: 22237149.
  15. Hoppe BS, Flampouri S, Su Z, Latif N, Dang NH, Lynch J, Joyce M, Sandler E, Li Z, Mendenhall NP. Effective Dose Reduction to Cardiac Structures using Protons Compared with 3DCRT and IMRT in Mediastinal Hodgkin Lymphoma. Int J Radiat Oncol Biol Phys. 2012 Mar 2. [Epub ahead of print] PubMed PMID: 22386373.
  16. Nichols RC, Huh SH, Henderson RH, Li Z, Flampouri S, D'Agostino HJ, Cury JD, Pham DC, Mendenhall NP, & Hoppe BH. Selective Nodal Irradiation of Regionally Advanced Non-small-cell Lung Cancer with Proton Therapy and IMRT: A Dosimetric Comparison. Thoracic Cancer 2011 (IN PRESS)
  17. Figura N, Flampouri S, Hopper K, Marcus R, Mendenhall NP, Hoppe BS. Consolidative Proton Therapy Following High-dose Chemotherapy and Autologous Stem Cell Transplant in an Adolescent with Relapsed Hodgkin Lymphoma. JAYAO 2011 1(2): 103-6
  18. Shi W, Nichols RC, Flampouri S, Hsi W, Li Z, Henderson RH, Mendenhall NP, Hoppe BS. Tumor Shrinkage during Proton-based Chemoradiation for Non-small-cell Lung Cancer May Necessitate Adaptive Replanning during Treatment. Hong Kong J Radiol. 2011;14:190-4
  19. Hoppe BS, Mamalui-Hunter M, Mendenhall NP, Li Z, Indelicato DJ. Improving the Therapeutic Ratio by Using Proton Therapy in Patients With Stage I or II Seminoma. Am J Clin Oncol. 2011 Nov 29. [Epub ahead of print] PubMed PMID: 22134517.
  20. Hoppe BS, Flampouri S, Su Z, Morris CG, Latif N, Dang NH, Lynch J, Li Z, Mendenhall NP. Consolidative Involved-Node Proton Therapy for Stage IA-IIIB Mediastinal Hodgkin Lymphoma: Preliminary Dosimetric Outcomes from a Phase II Study. Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):260-7. Epub 2011 Oct 17. PubMed PMID: 22014950.
  21. Hoppe B, Henderson R, Mendenhall WM, Nichols RC, Li Z, Mendenhall NP. Proton therapy for prostate cancer. Oncology (Williston Park). 2011 Jun;25(7):644-50, 652. Review. PubMed PMID: 21888265.
  22. Su Z, Zhang L, Ramakrishnan V, Hagan M, Anscher M. Investigations of interference between electromagnetic transponders and wireless MOSFET dosimeters: a phantom study. Med Phys. 2011 May;38(5):2450-4. PubMed PMID: 21776780; PubMed Central PMCID: PMC3188601.
  23. Mendenhall NP, Malyapa RS, Su Z, Yeung D, Mendenhall WM, Li Z. Proton therapy for head and neck cancer: rationale, potential indications, practical considerations, and current clinical evidence. Acta Oncol. 2011 Aug;50(6):763-71. Review. PubMed PMID: 21767172.
  24. Nichols RC, Huh SH, Hoppe BS, Henderson RH, Li Z, Flampouri S, D'Agostino HJ, Cury JD, Pham DC, Mendenhall NP. Protons safely allow coverage of high-risk nodes for patients with regionally advanced non-small-cell lung cancer. Technol Cancer Res Treat. 2011 Aug;10(4):317-22. PubMed PMID: 21728388.
  25. Nichols RC, Huh SN, Henderson RH, Mendenhall NP, Flampouri S, Li Z, D'Agostino HJ, Cury JD, Pham DC, Hoppe BS. Proton radiation therapy offers reduced normal lung and bone marrow exposure for patients receiving dose-escalated radiation therapy for unresectable stage iii non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer. 2011 Jul;12(4):252-7. doi: 10.1016/j.cllc.2011.03.027. Epub 2011 Apr 27. PubMed PMID: 21726825.
  26. Mendenhall WM, Henderson RH, Hoppe BS, Nichols RC, Mendenhall NP. Androgen Deprivation Therapy and Definitive Radiotherapy for Prostate Cancer. Am J Clin Oncol. 2011 Jun 18. [Epub ahead of print] PubMed PMID: 21694574.
  27. Jin H, Hsi W, Yeung D, Li Z, Mendenhall NP, Marcus RB Jr. Dosimetric characterization of whole brain radiotherapy of pediatric patients using modulated proton beams. J Appl Clin Med Phys. 2011 Jan 19;12(2):3308. PubMed PMID: 21587172.
  28. Nichols RC Jr, Morris CG, Hoppe BS, Henderson RH, Marcus RB Jr, Mendenhall WM, Li Z, Williams CR, Costa JA, Mendenhall NP. Proton radiotherapy for prostate cancer is not associated with post-treatment testosterone suppression. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1222-6. Epub 2011 May 11. PubMed PMID: 21570206.
  29. Mendenhall NP, Li Z, Hoppe BS, Marcus RB Jr, Mendenhall WM, Nichols RC, Morris CG, Williams CR, Costa J, Henderson R. Early outcomes from three prospective trials of image-guided proton therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):213-21. Epub 2010 Nov 17. PubMed PMID: 21093164.
  30. Hoppe BS, Huh S, Flampouri S, Nichols RC, Oliver KR, Morris CG, Mendenhall NP, Li Z. Double scattered proton-based stereotactic body radiotherapy for stage I lung cancer: a dosimetric comparison with photon-based stereotactic body radiotherapy. Radiother Oncol. 2010 Dec;97(3):425-30. Epub 2010 Oct 9. PubMed PMID: 20934768.
  31. Hsi WC, Indelicato DJ, Vargas C, Duvvuri S, Li Z, Palta J. In vivo verification of proton beam path by using post-treatment PET/CT imaging. Med Phys. 2009 Sep;36(9):4136-46. PubMed PMID: 19810487.
  32. Galloway TJ, Indelicato DJ, Amdur RJ, Swanson EL, Smith AA, Marcus RB. Second Tumors in Pediatric Patients Treated With Radiotherapy to the Central Nervous System. Am J Clin Oncol. 2011 Mar 4. [Epub ahead of print] PubMed PMID: 21383606.
  33. Jin H, Hsi W, Yeung D, Li Z, Mendenhall NP, Marcus RB Jr. Dosimetric characterization of whole brain radiotherapy of pediatric patients using modulated proton beams. J Appl Clin Med Phys. 2011 Jan 19;12(2):3308. PubMed PMID: 21587172.
  34. Galloway TJ, Indelicato DJ, Amdur RJ, Morris CG, Swanson EL, Marcus RB. Analysis of Dose at the Site of Second Tumor Formation After Radiotherapy to the Central Nervous System. Int J Radiat Oncol Biol Phys. 2011 Jan 13. [Epub ahead of print] PubMed PMID: 21236597.
  35. Hoppe BS, Huh S, Flampouri S, Nichols RC, Oliver KR, Morris CG, Mendenhall NP, Li Z. Double-scattered proton-based stereotactic body radiotherapy for stage I lung cancer: a dosimetric comparison with photon-based stereotactic body radiotherapy. Radiother Oncol. 2010 Dec;97(3):425-30. Epub 2010 Oct 9. PubMed PMID: 20934768.
  36. Mendenhall NP, Li Z, Hoppe BS, Marcus RB Jr, Mendenhall WM, Nichols RC, Morris CG, Williams CR, Costa J, Henderson R. Early Outcomes from Three Prospective Trials of Image-guided Proton Therapy for Prostate Cancer. Int J Radiat Oncol Biol Phys. 2010 Nov 17. [Epub ahead of print] PubMed PMID: 21093164.
  37. Jin H, Palta JR, Kim YH, Kim S. Application of a novel dose-uncertainty model for dose-uncertainty analysis in prostate intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):920-8. Epub 2010 Jun 30. PubMed PMID: 20584579.
  38. Indelicato DJ, Keole SR, Lagmay JP, Morris CG, Gibbs CP Jr, Scarborough MT, Islam S, Marcus RB Jr. Chest Wall Ewing Sarcoma Family of Tumors: Long-Term Outcomes. Int J Radiat Oncol Biol Phys. 2010 Aug 21. [Epub ahead of print] PubMed PMID: 20732765.
  39. Song WY, Huh SN, Liang Y, White G, Nichols RC, Watkins WT, Mundt AJ, Mell LK. Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer. J Appl Clin Med Phys. 2010 Aug 15;11(4):3255. PubMed PMID: 21081882.
  40. Hoppe BS, Flampouri S, Li Z, Mendenhall NP. Cardiac sparing with proton therapy in consolidative radiation therapy for Hodgkin lymphoma. Leuk Lymphoma. 2010 Aug;51(8):1559-62. PubMed PMID: 20578823.
  41. Chvetsov AV, Paige SL. The influence of CT image noise on proton range calculation in radiotherapy planning. Phys Med Biol. 2010 Mar 21;55(6):N141-9. Epub 2010 Feb 24. PubMed PMID: 20182006.
  42. Aldana PR, MacGregor TL, James HE, Marcus RB Jr, Indelicato DJ. Titanium screws as fiducial markers for image-guided stereotactic proton irradiation in pediatric central nervous system tumors: a technical report. Pediatr Neurosurg. 2010;46(3):227-31. Epub 2010 Nov 4. PubMed PMID: 21051922.
  43. Vargas C, Falchook A, Indelicato D, Yeung A, Henderson R, Olivier K, Keole S, Williams C, Li Z, Palta J. Proton therapy for prostate cancer treatment employing online image guidance and an action level threshold. Am J Clin Oncol. 2009 Apr;32(2):180-6. PubMed PMID: 19307953.
  44. Chera BS, Vargas C, Morris CG, Louis D, Flampouri S, Yeung D, Duvvuri S, Li Z, Mendenhall NP. Dosimetric study of pelvic proton radiotherapy for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):994-1002. Epub 2009 Jul 18. PubMed PMID: 19619961.
  45. Chera BS, Rodriguez C, Morris CG, Louis D, Yeung D, Li Z, Mendenhall NP. Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin's lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy. Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1173-80. Epub 2009 Apr 20. PubMed PMID: 19386423.
  46. Chvetsov AV, Dong L, Palta JR, Amdur RJ. Tumor-volume simulation during radiotherapy for head-and-neck cancer using a four-level cell population model. Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):595-602. PubMed PMID: 19596173.
  47. Hsi WC, Indelicato DJ, Vargas C, Duvvuri S, Li Z, Palta J. In vivo verification of proton beam path by using post-treatment PET/CT imaging. Med Phys. 2009 Sep;36(9):4136-46. PubMed PMID: 19810487.
  48. Mendenhall WM, Henderson RH, Nichols RC, Keole SR, Mendenhall NP. Postprostatectomy Radiotherapy for Prostate Cancer. Am J Clin Oncol. 2009 Jul 31. [Epub ahead of print] PubMed PMID: 19652581.
  49. Chera BS, Malyapa R, Louis D, Mendenhall WM, Li Z, Lanza DC, Yeung D, Mendenhall NP. Proton therapy for maxillary sinus carcinoma. Am J Clin Oncol. 2009 Jun;32(3):296-303. PubMed PMID: 19433966.
  50. Hsi WC, Moyers MF, Nichiporov D, Anferov V, Wolanski M, Allgower CE, Farr JB, Mascia AE, Schreuder AN. Energy spectrum control for modulated proton beams. Med Phys. 2009 Jun;36(6):2297-308. PubMed PMID: 19610318; PubMed Central PMCID: PMC2832068.
  51. Vargas C, Falchook A, Indelicato D, Yeung A, Henderson R, Olivier K, Keole S, Williams C, Li Z, Palta J. Proton therapy for prostate cancer treatment employing online image guidance and an action level threshold. Am J Clin Oncol. 2009 Apr;32(2):180-6. PubMed PMID: 19307953.
  52. Yeung AR, Vargas CE, Falchook A, Louis D, Olivier K, Keole S, Yeung D, Mendenhall NP, Li Z. Dose-volume differences for computed tomography and magnetic resonance imaging segmentation and planning for proton prostate cancer therapy. Int J Radiat Oncol Biol Phys. 2008 Dec 1;72(5):1426-33. Epub 2008 Aug 30. PubMed PMID: 18762391.
  53. Lin L, Vargas C, Hsi W, Indelicato D, Slopsema R, Li Z, Yeung D, Horne D, Palta J. Dosimetric uncertainty in prostate cancer proton radiotherapy. Med Phys. 2008 Nov;35(11):4800-7. PubMed PMID: 19070212.
  54. Paganetti H, Jiang H, Parodi K, Slopsema R, Engelsman M. Clinical implementation of full Monte Carlo dose calculation in proton beam therapy. Phys Med Biol. 2008 Sep 7;53(17):4825-53. Epub 2008 Aug 13. PubMed PMID: 18701772.
  55. Vargas C, Wagner M, Indelicato D, Fryer A, Horne D, Chellini A, McKenzie C, Lawlor P, Mahajan C, Li Z, Lin L, Keole S. Image guidance based on prostate position for prostate cancer proton therapy. Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1322-8. Epub 2008 May 28. PubMed PMID: 18472365.
  56. Vargas C, Wagner M, Indelicato D, Fryer A, Horne D, Chellini A, McKenzie C, Lawlor P, Mahajan C, Li Z, Lin L, Keole S. Image guidance based on prostate position for prostate cancer proton therapy. Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1322-8. Epub 2008 May 28. PubMed PMID: 18472365.
  57. Chvetsov AV, Palta JJ, Nagata Y. Time-dependent cell disintegration kinetics in lung tumors after irradiation. Phys Med Biol. 2008 May 7;53(9):2413-23. Epub 2008 Apr 17. PubMed PMID: 18421118.
  58. Vargas C, Wagner M, Mahajan C, Indelicato D, Fryer A, Falchook A, Horne D, Chellini A, McKenzie C, Lawlor P, Li Z, Lin L, Keole S. Proton therapy coverage for prostate cancer treatment. Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1492-501. PubMed PMID: 18374228.
  59. Vargas C, Wagner M, Mahajan C, Indelicato D, Fryer A, Falchook A, Horne D, Chellini A, McKenzie C, Lawlor P, Li Z, Lin L, Keole S. Proton therapy coverage for prostate cancer treatment. Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1492-501. PubMed PMID: 18374228.
  60. Vargas C, Fryer A, Mahajan C, Indelicato D, Horne D, Chellini A, McKenzie C, Lawlor P, Henderson R, Li Z, Lin L, Olivier K, Keole S. Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):744-51. Epub 2007 Sep 27. PubMed PMID: 17904306.
  61. Vargas C, Mahajan C, Fryer A, Indelicato D, Henderson RH, McKenzie C, Horne D, Chellini A, Lawlor P, Li Z, Oliver K, Keole S. Rectal dose-volume differences using proton radiotherapy and a rectal balloon or water alone for the treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1110-6. PubMed PMID: 17967305.
  62. Lu HM, Brett R, Engelsman M, Slopsema R, Kooy H, Flanz J. Sensitivities in the production of spread-out Bragg peak dose distributions by passive scattering with beam current modulation. Med Phys. 2007 Oct;34(10):3844-53. PubMed PMID: 17985630.
  63. Vargas C, Mahajan C, Fryer A, Indelicato D, Henderson RH, McKenzie C, Horne D, Chellini A, Lawlor P, Li Z, Oliver K, Keole S. Rectal dose-volume differences using proton radiotherapy and a rectal balloon or water alone for the treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1110-6. PubMed PMID: 17967305.
  64. Vargas C, Fryer A, Mahajan C, Indelicato D, Horne D, Chellini A, McKenzie C, Lawlor P, Henderson R, Li Z, Lin L, Olivier K, Keole S. Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):744-51. Epub 2007 Sep 27. PubMed PMID: 17904306.
  65. Slopsema RL, Kooy HM. Incorporation of the aperture thickness in proton pencil-beam dose calculations. Phys Med Biol. 2006 Nov 7;51(21):5441-53. Epub 2006 Oct 6. PubMed PMID: 17047262.

Select research demonstrating the benefits of proton therapy for:

Prostate Cancer

Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer

Proton therapy for prostate cancer: the initial Loma Linda University experience

Quality of life and satisfaction with outcome among prostate-cancer survivors

Head and Neck

Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique